Table 2

Poly-pu/py-rich sequence contexts of differences between humans and chimpanzees in human hot spot central regions. Differences between humans and chimpanzees within 166 bp of human hot spot mid points occurring in sequences at least 14 bp long consisting of over 80% poly-pu/py and at least 50% G/C. In each case, the hot spots are absent in chimpanzees. The chimpanzee sequence is shown in lower case.

Hot Spot

References

Sequence context

Distance of difference from human hot spot mid point (bp)

Beta-Globin

[15, 45]

CCTTTTCCCCTCCTACCCCTACTTT(C/t)T

133

DMB1

[4, 15]

GGGGGTGAGCAACAG(A/g)AA

35

DMB2

[4, 15]

GAGAGGAGAGAAGTGGAGTGGGAGAAAGAAGGAGAG(G/a)GACATAGAGAGAGGGA(G/a)(G/a)GAGGGGAG(C/-)GG(-/a) GGGAAG/AGAGAGAGAGCTGGA

115, 98, 97, 88, 85

DMB2

[4, 15]

GGGAGGGGAG(G/t)TGGA

51

DNA3

[4, 15]

GGGAGGCC(A/g)AGG(C/a)GGG

23,27

TAP2

[4, 15]

(C/g)CTTCATTCCATCC

83

Bagshaw et al. BMC Genomics 2006 7:179   doi:10.1186/1471-2164-7-179