Table 5

Significant genes exceeding expression cutoff across 5 sets of twins with ASD

Genbank#

Gene name or description

Mean log2 (ratio)*


Upregulated (log2(ratio) ≥ 0.58)

AA448599

F13A1, clotting factor XIIIa precursor

1.50

H15267

CHL1, neural cell adhesion molecule

1.10

AA521362

CR2 receptor

1.07

R00276

CD38 alt

0.83

W07099

NAGLU, N-acetylglucosaminidase, alpha

0.77

T49652

FLAP, ALOX5AP

0.77

AA044267

P2X5a

0.76

R40400

CHL1, neural cell adhesion molecule

0.75

H09567

PAG1

0.71

AI400399

CYP7B1

0.70

AA149640

FLT1

0.67

H17800

Unknown protein

0.67

H02307

FLAP, ALOX5AP

0.67

AA917693

Unknown protein

0.66

AI017382

ATXN7L1

0.66

AI091671

Unknown protein

0.65

N50114

PAG1

0.65

H95977

Nmd protein, PLA1A

0.65

AA040389

Unknown protein

0.64

H24011

Homeodomain-like protein

0.64

AI275120

Unknown protein

0.63

AA708955

SCHIP1, schwannomin interacting protein 1

0.62

AA406546

IL6ST, IL6 signal transducer, gp130

0.62

R79082

PTPRK

0.59

AI241341

CHL1, neural cell adhesion molecule

0.59

T61343

IL6ST, IL6 signal transducer, gp130

0.59

Downregulated (log2(ratio) ≤ -0.58)

AA446027

EGR2, Krox-20 homolog

-0.90

AA630734

seryl-tRNA synthetase

-0.86

R47893

CCL3L1

-0.80

AA682565

Unknown protein from neuroblastoma

-0.76

R78530

COTL1

-0.73

AA933744

ECAT11

-0.73

N58443

GPR55

-0.68

H99699

mitochondrial aconitase

-0.64

H03494

CD44

-0.63

AA450353

ELMOD1

-0.63

AA458965

IL32, natural killer cell protein, transcript 4

-0.63

R33402

SAMSN1

-0.62

AA111969

CD83 antigen

-0.60

AI380522

ITGB7, integrin beta-7 subunit

-0.60

AA682637

CHST2

-0.59


*Mean log2(ratio)of gene expression across 5 sets of twins with ASD. SAM analysis revealed 1281 significant genes with a median FDR of 15.6%. Only genes for which microarray data is available for all 3 sets of twins are included in this table. Genes in boldface type have been shown to be relevant to neurological development, structure, or function.

Hu et al. BMC Genomics 2006 7:118   doi:10.1186/1471-2164-7-118

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