Table 3

Network focus genes from Ingenuity Pathways Analysis meeting differential expression cutoff of log2(ratio) ≥ ± 0.58 (1.5-fold increase or decrease) in at least 1 set of twins.

GenBank #

Gene

Neurological function or disease*


Upregulated

T49652

ALOX5AP

neuronal signaling; possibly neurodegenerative diseases

AA991590

APOC1

AA147170

ALS4

ataxia-ocular apraxia

AA676466

ASS

involved in nitric oxide production

H21041

ATF3

extension of neurites

AA702350

AUTS2

Asperger's syndrome

AI341427

BCAT1

AA430367

CBS

R00276

CD38

AA283949

CDC14A

N67039

CDK6

H15267

CHL1

extension of neurites; organization of mossy fibers

AA521362

CR2

AA884403

CTF1

myelination, differentiation of neurons

AI371096

DAPK1

apoptosis of hippocampal neurons

W00789

DST

coalignment of neurofilaments, projection of axons; dysmyelination

AA448599

F13A1

stroke

AA149640

FLT1

VEGF-induced release of nitric oxide

AA070902

GGA2

AI375302

HMGB1

extension of neurites

AI539460

IL7

AA406546

IL6ST

myelination, development of motor neurons, retraction of dendrites

H09062

MLSTD1

W07099

NAGLU

neurogenesis; vacuolation of neurons

AA598611

NR4A2

neurogenesis; metabolism of dopamine

AA707195

NTRK2

survival of Purkinje cells; apoptosis of neurons

AA044267

P2RX5

H09567

PAG

possible role in chronic neuroinflammation

AA972337

PAWR

AA489629

PBEF1

AI016039

PLXNB2

R80217

PTGS2

activation of astrocytes; spatial memory in mice; apoptosis of neurons

AA495950

RRM2B

R27457

SLC38A2

AI091460

SOS1

N63153

SPRED1

AI040821

TERE1

AA970358

TSLP

Downregulated

AA779727

ADAM19

development of septum

R01732

AMPD3

AA478589

APOE

quantity/morphology of neurons; neurite extension; learning in mice

AA984646

C7orf2

AA448157

CYP1B1

AA446027

EGR2

myelination; development of motor neurons; routing of axons

AA149096

HCK

AA620511

HSPA8

W73790

IGLL1

AI380522

ITGB7

chronic demyelinating disease

AA679503

KIF1B

morphology and size of brain; neuron survival

AA029283

LARGE

T83159

LSP1

AI351740

LTB

neurological disorder in rats

AA022886

PITPNC1

AI126054

PTK2

AA173755

ROBO1

axon guidance

AA457700

SCD

neural regeneration

AA504211

TNFSF11

N68465

UAP1


Dataset included 1200 significant genes identified by SAM across three twin sets. FDR was 26.4%.

Genes in Boldfaced type are ones of neurological relevance.

*Descriptions of neurological functions were obtained from the Ingenuity Pathways Knowledge Base.

Hu et al. BMC Genomics 2006 7:118   doi:10.1186/1471-2164-7-118

Open Data