Table 3 |
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Network focus genes from Ingenuity Pathways Analysis meeting differential expression cutoff of log2(ratio) ≥ ± 0.58 (1.5-fold increase or decrease) in at least 1 set of twins. |
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GenBank # |
Gene |
Neurological function or disease* |
|
|
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|
Upregulated |
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|
ALOX5AP |
neuronal signaling; possibly neurodegenerative diseases |
|
|
APOC1 |
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|
ALS4 |
ataxia-ocular apraxia |
|
|
ASS |
involved in nitric oxide production |
|
|
ATF3 |
extension of neurites |
|
|
AUTS2 |
Asperger's syndrome |
|
|
BCAT1 |
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|
CBS |
||
|
CD38 |
||
|
CDC14A |
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|
CDK6 |
||
|
CHL1 |
extension of neurites; organization of mossy fibers |
|
|
CR2 |
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|
CTF1 |
myelination, differentiation of neurons |
|
|
DAPK1 |
apoptosis of hippocampal neurons |
|
|
DST |
coalignment of neurofilaments, projection of axons; dysmyelination |
|
|
F13A1 |
stroke |
|
|
FLT1 |
VEGF-induced release of nitric oxide |
|
|
GGA2 |
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|
HMGB1 |
extension of neurites |
|
|
IL7 |
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|
IL6ST |
myelination, development of motor neurons, retraction of dendrites |
|
|
MLSTD1 |
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|
NAGLU |
neurogenesis; vacuolation of neurons |
|
|
NR4A2 |
neurogenesis; metabolism of dopamine |
|
|
NTRK2 |
survival of Purkinje cells; apoptosis of neurons |
|
|
P2RX5 |
||
|
PAG |
possible role in chronic neuroinflammation |
|
|
PAWR |
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|
PBEF1 |
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|
PLXNB2 |
||
|
PTGS2 |
activation of astrocytes; spatial memory in mice; apoptosis of neurons |
|
|
RRM2B |
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|
SLC38A2 |
||
|
SOS1 |
||
|
SPRED1 |
||
|
TERE1 |
||
|
TSLP |
||
|
Downregulated |
||
|
ADAM19 |
development of septum |
|
|
AMPD3 |
||
|
APOE |
quantity/morphology of neurons; neurite extension; learning in mice |
|
|
C7orf2 |
||
|
CYP1B1 |
||
|
EGR2 |
myelination; development of motor neurons; routing of axons |
|
|
HCK |
||
|
HSPA8 |
||
|
IGLL1 |
||
|
ITGB7 |
chronic demyelinating disease |
|
|
KIF1B |
morphology and size of brain; neuron survival |
|
|
LARGE |
||
|
LSP1 |
||
|
LTB |
neurological disorder in rats |
|
|
PITPNC1 |
||
|
PTK2 |
||
|
ROBO1 |
axon guidance |
|
|
SCD |
neural regeneration |
|
|
TNFSF11 |
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|
UAP1 |
||
|
|
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|
Dataset included 1200 significant genes identified by SAM across three twin sets. FDR was 26.4%. Genes in Boldfaced type are ones of neurological relevance. *Descriptions of neurological functions were obtained from the Ingenuity Pathways Knowledge Base. |
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Hu et al. BMC Genomics 2006 7:118 doi:10.1186/1471-2164-7-118 |
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