Table 2

Expression of ASS, CHL1, and FLAP in 2 sets of discordant monozygotic twins relative to expression levels in their respective normal siblings

Gene name

Genbank #

A1

M1

A2

M2


ASS

AA676405

0.65 (0.81)*

-0.13 (0.27)

1.77 (3.04)

0.18 (0.97)

CHL1

H15267

1.60 (1.64)

0.67 (1.39)

1.15 (0.78)

0.95 (0.60)

FLAP

T49652

0.71 (1.10)

0.13 (0.77)

1.40 (1.45)

-0.09 (-0.39)


Values are mean log2(ratio) measures of gene expression between a twin and his respective normal sibling, obtained by DNA microarray analyses with dye reversal replicates

* Values in parentheses are mean log2(ratio) measures obtained by triplicate qPCR analyses.

A = autistic twin as diagnosed by ADI-R scoresheet

M = more mildly affected twin who did not meet ADI-R criteria for autism

Hu et al. BMC Genomics 2006 7:118   doi:10.1186/1471-2164-7-118

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