Table 7

Nonsynonymous SNP in MMU2, 9 and 17 hg modifier candidate genes predicted by SIFT and Polyphen to alter protein function

Gene

MMU

Mbp

AAÄ^a

B6/CAST^b Polyphen

CAST/B6 Polyphen

B6/CAST SIFT

CAST/B6 SIFT

Nmi

2

52.0

R243C

B

B

T

D

Mtx2

2

74.7

T1099M

PSD

PSD

T

D

Ubr1

2

120.6

A1371T

B

B

D

T

Ptpns1

2

129.3

H224N

PBD

PBD

T

T

Ubce7ip5

2

130.3

A314P

PSD

PSD

T

T

2

I366T

B

B

T

D

Plcg1

2

160.5

T1165A

B

B

T

D

Mmp9

2

164.7

A514P

B

B

D

D

2

P639L

PBD

PBD

T

T

Tyk2

9

21.0

R234H

PSD

PSD

T

T

C831S

PSD

PSD

T

T

T1099M

PSD

PSD

T

D

Vav

17

55.5

Q29H

PSD

PBD

T

T

Q53H

PBD

PSD

T

T

Q65H

PBD

PSD

T

D

MMU, mouse chromosome; AA, amino acid; PBD, probably damaging, PSD, possibly damaging; B, Benign; T, tolerated and D, deleterious.

^a Amino acid change, first residue listed corresponds to the CAST allele and second corresponds to the B6 allele.

^b Indicates which allele was designated as "mutant", i.e. B6/CAST, B6 allele is mutant and CAST is wild type.

Farber et al. BMC Genomics 2006 7:102   doi:10.1186/1471-2164-7-102