Table 3

Summary of G-protein signaling genes in unc-4::GFP neurons. Genes either known to function in C. elegans motor neuron G-protein signaling pathways or likely to have a role therein (e.g. SER-4) are listed here with KOG descriptions. Transcripts are listed as either enriched with statistical rank (top) or as EGs (bottom).

Cosmid Name

Common Name

Statistical Rank

KOG Description

Enriched

F47D12.1

gar-2

245

7 transmembrane receptor

Y40H4A.1

gar-3

421

Muscarinic acetylcholine receptor

F15A8.5d

dop-1

683

7 transmembrane receptor

Y22D7AR.13

ser-4

680

7 transmembrane receptor

Y41G9A.4

769

GABA-B ion channel receptor subunit GABABR1 and related subunits, G-protein coupled receptor superfamily

M01D7.7a

egl-30

124

G protein subunit Galphaq/Galphay, small G protein superfamily

F28C1.2

egl-10

872

G protein signaling regulators

F57F5.5

pkc-1

743

Serine/threonine protein kinase

F17C8.1

acy-1

884

Adenylyl cyclase

R07E4.6

kin-2

467

cAMP-dependent protein kinase types I and II, regulatory subunit

Present (EGs)

Y69A2AR.1

ric-8

Signaling protein RIC-8/synembryn (regulates neurotransmitter secretion)

C16C2.2a

eat-16

G protein signaling regulators

B0348.4a

egl-8

Phospholipase C

F52A8.2

gpb-2

G-protein beta subunit

C26C6.2

goa-1

G-protein alpha subunit (small G protein superfamily)

ZK542.2a

unc-13

Neurotransmitter release regulator, UNC-13

C09E10.2a

dgk-1

Diacylglycerol kinase

R06A10.2

gsa-1

G protein subunit Galphas, small G protein superfamily

Fox et al. BMC Genomics 2005 6:42   doi:10.1186/1471-2164-6-42