Genomic landscape surrounding the most prominent UCR clusters in the human genome. UCRs were counted by sliding a 500 kb window along the chromosomes. Overlapping UCR-containing windows were merged into a single cluster span. Each of the regions shows a 4 MB region around the corresponding UCR cluster. The cluster span coordinates correspond to the human genome NCBI build 33 (UCSC hg15, April 2003). Transcription factor genes are colored according to structural class. UCR clusters are visibly correlated with transcription factor genes; other developmental regulators that do not contain any of the probed protein domains were located manually (boxed), such as the autism susceptibility gene (chromosome 7, number 37) and the DACH gene (chromosome 13, number 10). The numbers correspond to annotations in [Additional file 6 and 7]. The figure was created with the help of the Bio::Graphics Perl library.
Sandelin et al. BMC Genomics 2004 5:99 doi:10.1186/1471-2164-5-99