Additional File 1:

List and annotation of 360 expressed sequences ("immune genes").

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Additional File 10:

FASTA sequences and the corresponding coordinates on the human and mouse genome assemblies (May 2004) of the promoter regions used in the analysis and displayed in figures 2 and 4.

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Additional File 2:

Using K-means clustering in GeneSpring (Version 4.2.1), 160 annotated genes, were divided into distinct sets based on similarity of expression patterns across 15 tissues. Tissues were given equal weight, the number of clusters was set at 20, and similarity was measured by standard correlation.

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Additional File 11:

FASTA sequences and the corresponding coordinates on the human and mouse genome assemblies (May 2004) of the promoter regions used in the analysis and displayed in figures 2 and 4.

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Additional File 3:

CisMols display of location and composition of clusters of cis-elements that are putative regulatory modules for the genes in various groups (test and control). Each colored cube indicates a cluster of 3 or more cis-elements with at least one "lymphoid element". The region searched is upstream 3 kb and downstream 100 bp of transcription start site (as defined by the respective mRNAs from NCBI's RefSeq database). The legend in the lower left half of the figure indicates the composition of each of the modules and the genes that share them.

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Additional File 4:

CisMols display of location and composition of clusters of cis-elements that are putative regulatory modules for the genes in various groups (test and control). Each colored cube indicates a cluster of 3 or more cis-elements with at least one "lymphoid element". The region searched is upstream 3 kb and downstream 100 bp of transcription start site (as defined by the respective mRNAs from NCBI's RefSeq database). The legend in the lower left half of the figure indicates the composition of each of the modules and the genes that share them.

Format: PDF Size: 939KB Download file

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Additional File 5:

CisMols display of location and composition of clusters of cis-elements that are putative regulatory modules for the genes in various groups (test and control). Each colored cube indicates a cluster of 3 or more cis-elements with at least one "lymphoid element". The region searched is upstream 3 kb and downstream 100 bp of transcription start site (as defined by the respective mRNAs from NCBI's RefSeq database). The legend in the lower left half of the figure indicates the composition of each of the modules and the genes that share them.

Format: PDF Size: 41KB Download file

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Additional File 6:

CisMols display of location and composition of clusters of cis-elements that are putative regulatory modules for the genes in various groups (test and control). Each colored cube indicates a cluster of 3 or more cis-elements with at least one "lymphoid element". The region searched is upstream 3 kb and downstream 100 bp of transcription start site (as defined by the respective mRNAs from NCBI's RefSeq database). The legend in the lower left half of the figure indicates the composition of each of the modules and the genes that share them.

Format: PDF Size: 180KB Download file

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Additional File 7:

CisMols display of location and composition of clusters of cis-elements that are putative regulatory modules for the genes in various groups (test and control). Each colored cube indicates a cluster of 3 or more cis-elements with at least one "lymphoid element". The region searched is upstream 3 kb and downstream 100 bp of transcription start site (as defined by the respective mRNAs from NCBI's RefSeq database). The legend in the lower left half of the figure indicates the composition of each of the modules and the genes that share them.

Format: PDF Size: 134KB Download file

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Additional File 8:

CisMols display of location and composition of clusters of cis-elements that are putative regulatory modules for the genes in various groups (test and control). Each colored cube indicates a cluster of 3 or more cis-elements with at least one "lymphoid element". The region searched is upstream 3 kb and downstream 100 bp of transcription start site (as defined by the respective mRNAs from NCBI's RefSeq database). The legend in the lower left half of the figure indicates the composition of each of the modules and the genes that share them.

Format: PDF Size: 312KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional File 9:

CisMols display of location and composition of clusters of cis-elements that are putative regulatory modules for the genes in various groups (test and control). Each colored cube indicates a cluster of 3 or more cis-elements with at least one "lymphoid element". The region searched is upstream 3 kb and downstream 100 bp of transcription start site (as defined by the respective mRNAs from NCBI's RefSeq database). The legend in the lower left half of the figure indicates the composition of each of the modules and the genes that share them.

Format: PDF Size: 117KB Download file

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Additional File 12:

Tissue lists used in the generation of microarray profile data.

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