|
Differential Gene Expression in LAPE Cells Relative to LAPN Cells |
||
| Growth Factor/Hormone Signaling |
Accession |
fold-change |
|
|
||
| phospholipase C gamma 1 |
W65065 |
4.1 |
| uPAR |
X62701 |
3.5 |
| MDK1 (neuronal tyrosine kinase receptor) |
X79082 |
3.2 |
| FGF-6 |
M92416 |
3.1 |
| TC21 ras-like protein |
W91283 |
3.1 |
| tyrosine kinase SEK receptor precursor |
W53668 |
3.0 |
| GC Binding Protein |
Z36270 |
3.0 |
| FGFR-4 |
X59927 |
2.9 |
| casein kinase II alpha |
AA153726 |
2.8 |
| FYN tyrosine protein kinase |
W35964 |
2.6 |
| ERK2 |
W51403 |
2.5 |
| PIP5KII |
P48426 |
2.5 |
| P2X purinoceptor 3 (ATP receptor) |
AA050453 |
2.3 |
| IRG47 GTP binding-protein |
M63630 |
2.3 |
| p120GAP |
P09851 |
2.2 |
| PDGF/VEGF member |
X99572 |
2.1 |
| FGF-4 |
X14849 |
2.0 |
| CAP adenylyl cyclase-associated protein |
L12367 |
2.0 |
| N-ras |
X13664 |
1.9 |
| protein-tyrosine phosphatase epsilon precursor |
U35368 |
1.7 |
| guanine nucleotide binding protein G(K) alpha |
W64628 |
1.6 |
| brain-derived neurotrophic factor |
X55573 |
1.6 |
| Grg1 groucho-related gene 1 protein |
U61362 |
1.5 |
| SOS 2 (ras GEF) |
Z11664 |
1.5 |
| proteinase activated receptor 2, PAR2 |
Z48043 |
-1.8 |
| receptor of activated protein kinase C (RACK1) |
AA024231 |
-1.8 |
| PAK p21-activated kinase |
AA117286 |
-2.0 |
| guanine nucleotide binding protein gamma-7 |
W64628 |
-2.1 |
| ERF1 EGF-response factor 1 |
W33538 |
-2.3 |
| Fgd1 (faciogenital dysplasis) (Cdc42 GEF) |
U22325 |
-2.7 |
| 5-HT5B serotonin receptor |
X69867 |
-2.7 |
| chemokine receptor type 4 |
P70658 |
-2.7 |
| A-raf |
AA104043 |
-3.4 |
| FGF-7 |
Z22703 |
-3.5 |
| GRK5 |
W36620 |
-3.7 |
| Emr1 receptor (EGF-7 TM family) |
U66890 |
-4.3 |
| gliostatin (PD-ECGF) |
AA008687 |
-5.9 |
| MAPKK 3 |
W29331 |
-8.2 |
| Growth and Oncogenesis |
Accession |
fold-change |
| semaphorin E |
X85994 |
5.0 |
| Evi-1 proto-oncogene |
X54989 |
3.1 |
| interferon-inducible protein 9–27 |
P13164 |
2.5 |
| testis-specific c-abl protein |
J02995 |
2.5 |
| MAF proto-oncogene |
W77346 |
2.3 |
| MUC18 melanoma-associated antigen |
AA088962 |
2.3 |
| B94 TNF-α-induced early response gene |
L24118 |
2.1 |
| calpactin I light chain |
M16465 |
2.1 |
| Fra 1 |
U34245 |
2.0 |
| cell division protein FTSH homolog |
AA014057 |
1.9 |
| ALL-1 zinc finger protein HRX |
W62585 |
1.9 |
| LAF-4 lymphoid nuclear protein |
U34361 |
1.7 |
| calpactin I heavy chain |
D10024 |
1.6 |
| insulin-induced growth response protein CL-6 |
AA030483 |
1.5 |
| mage-like protein |
W51344 |
-1.9 |
| TRAF4 |
X92346 |
-2.1 |
| rearranged mutant c-myb gene |
M13990 |
-2.1 |
| Ing1 |
AF177757 |
-2.2 |
| Fra 2 |
P15408 |
-2.8 |
| ERV1 |
AA034842 |
-2.9 |
| MAGE-11 |
W51344 |
-3.4 |
| MCF2 Dbl proto-oncogene |
W98059 |
-4.0 |
| HSP 90 alpha |
AA117183 |
-9.1 |
| membrane glycoprotein |
Z22552 |
-10.7 |
| Cell Cycle/DNA Replication |
Accession |
fold-change |
| GADD153 |
X67083 |
45.7 |
| wee1 kinase |
D30743 |
2.3 |
| RAD54 DNA-repair gene |
X97796 |
1.9 |
| 14-3-3 protein tau/theta |
W61758 |
1.7 |
| G1/S-specific cyclin D1 |
P25322 |
1.7 |
| cell division-associated protein BIMB. |
AA165880 |
-1.5 |
| proliferating-cell nuclear antigen |
AA088121 |
-1.7 |
| CKS-2 cyclin-dep kinases regulatory subunit 2 |
X54942 |
-1.8 |
| GADD45 |
AA138777 |
-2.1 |
| gas1 |
X65128 |
-2.5 |
| SKCDC25 |
Q02342 |
-4.1 |
| FLAP endonuclease-1; FEN-1 |
AA072149 |
-7.5 |
| Cytoskeleton |
Accession |
fold-change |
| clip 170 (restin) |
W13214 |
4.2 |
| septin 2 (NEDD5 PROTEIN) |
W51490 |
3.6 |
| KIF4 kinesin-like protein |
AA109999 |
3.4 |
| neuraxin |
AA048974 |
2.1 |
| kinesin light chain 1 |
W81858 |
2.1 |
| axonemal dynein heavy chain |
Z83815 |
1.9 |
| septin 4 (BRAIN PROTEIN H5) |
AA020101 |
1.8 |
| gelsolin |
J04953 |
1.7 |
| myosin regulatory light chain 2, smooth muscle isoform |
W18383 |
-4.5 |
| NF2 neurofibromatosis type 2 isoform I |
X74671 |
-5.7 |
| Cell Adhesion and Extracellular matrix |
Accession |
fold-change |
| mast cell protease 5 precursor |
AA032912 |
6.3 |
| osteopontin |
X51834 |
2.3 |
| neural cell adhesion molecule (NCAM-140) |
X07233 |
2.1 |
| anti-von Willebrand factor antibody NMC-4 kappa chain |
U90238 |
2.1 |
| inter-alpha-inhibitor H2 |
X70392 |
2.0 |
| galectin-3 |
P16110 |
1.8 |
| extensin precursor |
W75015 |
1.7 |
| E-selectin ligand-1 (ESL-1) |
X84037 |
-1.6 |
| microfibril associated glycoprotein precursor (MAGP) |
W08049 |
-1.8 |
| integrin beta-5 subunit precursor |
W14823 |
-2.0 |
| lectin lambda |
U56734 |
-3.3 |
| type IV collagenase |
Z27231 |
-26.0 |
| Ion Transporters |
Accession |
fold-change |
| CMP-sialic acid transporter |
Z71268 |
2.5 |
| V-ATPase A |
U13837 |
2.2 |
| AKR voltage-gated potassium-channel (KCNA4) |
U03723 |
2.1 |
| potassium channel protein NGK2 |
Y07521 |
2.0 |
| glucose transporter type 4 insulin-responsive (GT2) |
M23383 |
-4.0 |
| synaptic vesicle amine transporter |
AA166512 |
-7.1 |
| V-ATPase E |
W50167 |
-10.4 |
| Transcriptional Regulation |
Accession |
fold-change |
| histone H3.1 |
X16496 |
6.2 |
| retinoic acid-binding protein |
X51715 |
3.7 |
| HNF-3/Forkhead homolog II |
Q61575 |
3.2 |
| transcription regulatory protein MCP-1 (POU 1) |
D13801 |
3.0 |
| NfiA2-protein (nuclear factor 1) |
Y07691 |
1.8 |
| transcription factor C1 |
U53925 |
-1.5 |
| GATA-6 |
U51335 |
-1.6 |
| zinc finger protein 91 |
Q05481 |
-1.9 |
| winged-helix gene, htlf |
Y12656 |
-2.2 |
| C/EBP delta |
X61800 |
-2.5 |
| retinoid X receptor-beta |
X66224 |
-2.9 |
| HLX homeo box protein |
X58250 |
-3.8 |
| Nucleotide Processing |
Accession |
fold-change |
| myoblast cell surface antigen |
W98426 |
5.6 |
| activator 1 37 KD subunit |
W85565 |
3.6 |
| RNA polymerase II large subunit |
M12130 |
3.0 |
| DNA-directed RNA polymerase III largest subunit |
W54015 |
3.0 |
| uridylate kinase |
AA114781 |
1.8 |
| U1RNA-associated 70-kDa protein |
X15769 |
-1.6 |
| U6 snRNA-associated protein |
W34985 |
-3.3 |
| Protein Processing |
Accession |
fold-change |
| eukaryotic peptide chain releasing factor GTP-binding subunit |
AA105072 |
2.5 |
| putative ATP-dependent RNA helicase PL10 |
AA125293 |
2.4 |
| 40S ribosomal protein S10 |
W13807 |
2.1 |
| tryptophanyl-tRNA synthetase |
AA051240 |
1.8 |
| ubiquitin carboxyl-terminal hydrolase (protease 4) |
W50538 |
1.6 |
| ribosomal protein L32 |
K02060 |
-1.8 |
| elongation factor TS (forms complex with EF-tu) |
W70475 |
-1.9 |
| ubiquitin carboxyl-terminal hydrolase (protease 8) |
AA087408 |
-2.4 |
| elongation factor 2 (EF-2) |
P05086 |
-2.6 |
| phenylalanine – tRNA synthetase |
AA020069 |
-3.8 |
| threonyl-tRNA synthetase |
AA051240 |
-4.5 |
| elongation factor TU |
AA088054 |
-5.4 |
| Stress-related |
Accession |
fold-change |
| glutathione peroxidase |
AA038094 |
2.9 |
| thioredoxin-dependent peroxide reductase 2 |
W85659 |
1.6 |
| superoxide dismutase 3 (SOD3) |
X84940 |
-1.5 |
| thioredoxin-dependent peroxide reductase 1 |
W88176 |
-2.1 |
| glutathione S-transferase, GSTT1 |
X98055 |
-3.2 |
| 24p3 lipocalin |
X81627 |
-23.7 |
| Carbohydrate Metabolism |
Accession |
fold-change |
| pyruvate kinase M2 |
AA168931 |
3.8 |
| hexokinase |
P24049 |
2.4 |
| phosphofructose kinase-2 |
P70265 |
2.3 |
| acetyl-Coenzyme A acetyltransferase 2 |
BC000408 |
-1.8 |
| Ldh-2 |
X51905 |
-1.9 |
| ERV1 |
AA034842 |
-2.9 |
| galactokinase 2 |
AA145750 |
-2.9 |
| citrate transport protein |
AA108822 |
-2.9 |
| phosphorylase B kinase gamma catalytic subunit |
AA015461 |
-3.7 |
| fructose-1,6-bisphosphatase |
P19112 |
-4.0 |
| lactate dehydrogenase |
P00338 |
-4.0 |
| Electron Transport and Oxidative Phosphorylation |
Accession |
fold-change |
| ATP synthase (subunit D) |
P31399 |
6.4 |
| NADH-ubiquinone oxidoreductase (complex I) |
BC002772 |
2.3 |
| cytochrome C oxidase VIa |
U08439 |
2.2 |
| ATP synthase P1precursor (subunit C) |
W16250 |
2.0 |
| ATP synthase (subunit A) |
W49135 |
1.8 |
| mitochondrial inner membrane protease subunit 1 |
AA009014 |
-1.5 |
| cytochrome P450IIIA |
D26137 |
-3.9 |
| Trafficking |
Accession |
fold-change |
| beta adaptin |
P21851 |
1.9 |
| rab10 |
AA119194 |
1.5 |
| rab8 |
P22128 |
3.3 |
| rab11b |
L26528 |
-1.5 |
| BRAIN PROTEIN I47(similar to yeast SEC 17) |
W55684 |
-1.7 |
| PROTEIN TRANSPORT PROTEIN SEC22 |
AA023107 |
-1.8 |
| SYNAPTOBREVIN 2 |
AA072236 |
-4.6 |
| Immune-related Signaling |
Accession |
fold-change |
| anti-DNA immunoglobulin heavy chain IgG |
U55461 |
3.5 |
| immunoglobulin rearranged kappa chain |
ET62056 |
3.4 |
| complement receptor type 2 precursor (CR2) |
W98124 |
2.6 |
| thymocyte B cell antigen precursor |
AA068606 |
2.3 |
| immunoglobulin alpha heavy chain |
J00475 |
2.2 |
| interferon gamma receptor second chain |
U69599 |
1.8 |
| pre-B cell enhancing factor precursor |
W59723 |
1.8 |
| interferon beta type 2 |
V00756 |
1.7 |
| anti-DNA immunoglobulin light chain IgG |
U55604 |
1.6 |
| FK506-binding protein precursor (FKBP-13) |
AA163272 |
-1.5 |
| immunoglobulin light chain Fv-fragment |
Y10941 |
-2.3 |
| Ig 1B4.B5 heavy chain mRNA for mouse cytochrome c |
ET61726 |
-2.3 |
| immunoglobulin-like receptor PIRA1 |
U96682 |
-2.8 |
| CD10 neutral endopeptidase (pre-B cell differentiation) |
M81591 |
-3.1 |
| immunoglobulin variable region, heavy chain |
X95878 |
-3.3 |
| immune-responsive gene 1 (Irg1) |
L38281 |
-3.9 |
| anti-DNA immunoglobulin heavy chain IgG |
U55550 |
-4.1 |
| immunoglobulin light chain variable region |
ET61272 |
-7.8 |
| immunoglobulin heavy chain variable region |
ET62261 |
-8.2 |
| Miscellaneous |
Accession |
fold-change |
| parotid secretory protein |
X01697 |
4.0 |
| amyloid-like protein 1 precursor |
Q03157 |
4.0 |
| liver receptor homologous protein |
M81385 |
1.7 |
| oncomodulin |
Z48238 |
-1.6 |
| tctex-1 |
M25825 |
-1.6 |
| beta-hydroxysteroid dehydrogenase type 2 |
X90647 |
-2.8 |
| C57BL/6J ob/ob haptoglobin |
M96827 |
-2.9 |
| angiotensin-converting enzyme |
J04947 |
-3.2 |
| Swiss Webster demilune cell-specific salivary gland protein |
W15826 |
-7.1 |
| neurexophilin 1 |
U56651 |
-7.8 |
Putney and Barber BMC Genomics 2004 5:46 doi:10.1186/1471-2164-5-46 |
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