Figure 1.

Ligation of OCP to genomic DNA target Open circle probe (OCP) anneals to genomic DNA target, and the 3' base either base pairs with the target (red) or creates a mismatch (blue). The matched OCP is circularized by ligase, and becomes topologically linked to the target.

Alsmadi et al. BMC Genomics 2003 4:21   doi:10.1186/1471-2164-4-21
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