Additional files 1.
Physical map of the Blau syndrome interval showing BAC clone contigs and markers. G3 RH indicates the map, generated from radiation hybrid data, which was used to estimate the size of each gap in the BAC contigs. NCBI 25 is the map based on NCBI build 25, the map from the NCBI that was current when the BAC contig was constructed and is shown at the top. NCBI 29 is the current map based on NCBI build 29. Horizontal arrowheads with "Cen" and "Tel" indicate the orientation of the centromere and q-telomere respectively. Transcripts, using HUGO (LocusLink) symbols of named loci are indicated below the scale line of build 29. Boxed symbols indicate that the genes were located on clones in this study, either to locate them or to verify their location. Horizontal lines above transcript symbols indicate approximate placement. For the BAC contig, horizontal lines are schematic representations of BAC clones and are not to scale; BACs are identified by text below each horizontal line. BAC clones are shown in clusters according to the library, CITB or RPC-11, from which they were isolated. Vertical bars indicate BAC clones that are positive for the corresponding markers indicated in vertical text above the BAC contigs. Two genes, matrix metalloproteinase 2 (MMP2) and carboxylesterase 1 (CES1) were mapped using markers developed here and are indicated as boxed markers. Caspase recruitment domain family member 15 (CARD15) was located to 327F22 using an exon 4-specific PCR and is also indicated as a boxed marker. A dotted line box around clones indicates the specific clones that differed between the FPC contigs and this map. Numbered vertical arrows on the bottom indicate the three gaps in the BAC contig.
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Wang et al. BMC Genomics 2002 3:24 doi:10.1186/1471-2164-3-24