Open Access Highly Accessed Correspondence

Relationship between genome and epigenome - challenges and requirements for future research

Geneviève Almouzni1, Lucia Altucci2, Bruno Amati34, Neil Ashley5, David Baulcombe6, Nathalie Beaujean7, Christoph Bock8, Erik Bongcam-Rudloff9, Jean Bousquet10, Sigurd Braun11, Brigitte Bressac-de Paillerets12, Marion Bussemakers13, Laura Clarke14, Ana Conesa15, Xavier Estivill16, Alireza Fazeli17, Neža Grgurević18, Ivo Gut19, Bastiaan T Heijmans20, Sylvie Hermouet21, Jeanine Houwing–Duistermaat20, Ilaria Iacobucci22, Janez Ilaš18, Raju Kandimalla23, Susanne Krauss-Etschmann24, Paul Lasko25, Sören Lehmann26, Anders Lindroth27, Gregor Majdič18, Eric Marcotte28, Giovanni Martinelli22, Nadine Martinet29, Eric Meyer30, Cristina Miceli31, Ken Mills32, Maria Moreno-Villanueva33, Ghislaine Morvan34, Dörthe Nickel1, Beate Niesler35, Mariusz Nowacki36, Jacek Nowak37, Stephan Ossowski16, Mattia Pelizzola3, Roland Pochet38, Uroš Potočnik39, Magdalena Radwanska40, Jeroen Raes414243, Magnus Rattray44, Mark D Robinson45, Bernard Roelen46, Sascha Sauer47, Dieter Schinzer48, Eline Slagboom20, Tim Spector49, Hendrik G Stunnenberg13, Ekaterini Tiligada50, Maria-Elena Torres-Padilla51, Roula Tsonaka20, Ann Van Soom52, Melita Vidaković53 and Martin Widschwendter23*

Author Affiliations

1 Institut Curie – Research Center, UMR3664 CNRS/IC, 26 rue d’Ulm, Paris cedex 05 F-75248, France

2 Seconda Università degli Studi di Napoli, Naples, IT, Italy

3 Istituto Italiano di Tecnologia (IIT), Milan, IT, Italy

4 Istituto Europeo di Oncologia (IEO), Milan, IT, Italy

5 University of Oxford, Oxford, UK

6 Cambridge University, Cambridge, UK

7 INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy-en-Josas, FR F-78350, France

8 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, AT, Austria

9 Swedish University of Agricultural Sciences, Uppsala, SE, Sweden

10 University of Montpellier, Montpellier, FR, France

11 Ludwig Maximilians University of Munich, Munich, DE, Germany

12 Gustave-Roussy, Villejuif, FR, France

13 Radboud University Nijmegen, Nijmegen, NL, Netherlands

14 European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK

15 Centro de Investigación Príncipe Felipe, Valencia, ES, Spain

16 Centre for Genomic Regulation (CRG), Barcelona, Spain and Universitat Pompeu Fabra (UPF), Barcelona, Spain

17 University of Sheffield, Sheffield, UK

18 Center for Animal Genomics, Institute of physiology, Veterinary Faculty, University of Ljubljana and Medical school, University of Maribor, Ljubljana, Slovenia

19 Centre Nacional d'Anàlisi Genòmica, Barcelona, ES, Spain

20 Leiden University Medical Center, Leiden, NL, Netherlands

21 Centre Hospitalier Universitaire, Nantes, FR, France

22 University of Bologna, Bologna, IT, Italy

23 Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London, 74 Huntley Street, London WC1E 6AU, UK

24 Helmholtz Center, Munich, DE, Germany

25 Department of Biology, McGill University, Montreal, QC, Canada

26 Karolinska Institute, Stockholm, SE, Sweden

27 German Cancer Research Centre, Heidelberg, DE, Germany

28 Canadian Institutes of Health Research, Ottawa, CA, Canada

29 Institut de Chimie, UMR CNRS 7272/UNSA, Nice, FR, France

30 Centre National de la Recherche Scientifique, Paris, FR, France

31 University of Camerino, Camerino, IT, Italy

32 Queen's University Belfast, Belfast, UK

33 University of Konstanz, Konstanz, DE, Germany

34 CNRS UMR7221, Museum National d'Histoire Naturelle, Paris, FR, France

35 Universitäts Klinikum Heidelberg, Heidelberg, DE, Germany

36 University of Bern, Bern, CH, Switzerland

37 Institute of Biochemistry and Biophysics, PAS, Warsaw, PL, Poland

38 Universite Libre de Bruxelles, Bruxelles, BE, Belgium

39 University of Maribor, Maribor, SI, Slovenia

40 Science Europe, Brussel, Europe, BE, Belgium

41 Vrije Universiteit Brussel, Brussel, BE, Belgium

42 Katholieke Universiteit Leuven, Leuven, BE, Belgium

43 Vlaams Instituut voor Biotechnologie, Gent, BE, Belgium

44 University of Manchester, Manchester, UK

45 University of Zurich, Zurich, CH, Switzerland

46 Utrecht University, Utrecht NL, The Netherlands

47 Max-Planck-Institute for Molecular Genetics, Berlin, DE, Germany

48 University of Magdeburg, Magdeburg, DE, Germany

49 Kings College London, London, UK

50 Medical School University of Athens, Athens, GR, Greece

51 Institut de Génétique et de Biologie Molécularie et Cellulaire, Strasbourg, FR, France

52 University of Gent, Gent, BE, Belgium

53 Institute for Biological Research, Belgrade, RS, Serbia

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BMC Genomics 2014, 15:487  doi:10.1186/1471-2164-15-487

Published: 18 June 2014

Abstract

Understanding the links between genetic, epigenetic and non-genetic factors throughout the lifespan and across generations and their role in disease susceptibility and disease progression offer entirely new avenues and solutions to major problems in our society. To overcome the numerous challenges, we have come up with nine major conclusions to set the vision for future policies and research agendas at the European level.

Keywords:
Genome; Epigenome; Microbiome; Environment