Figure 1.

Strategy employed to identify primary JunD targets in bone marrow derived macrophages. We performed Jund RNAi and compared whole genome expression profiling in macrophages (basal and stimulated with LPS, 100ng/ml, 8h) transfected with scrambled siRNA to those transfected with Jund siRNA. ChIP-Seq analysis was performed in WKY and WKY.LCrgn2 BMDMs (basal and stimulated with LPS, 100ng/ml, 2h). Transcripts showing a fold change > 3 in the RNAi dataset were examined for JunD/AP1 peaks.

Hull et al. BMC Genomics 2013 14:92   doi:10.1186/1471-2164-14-92
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