Figure 4.

Evolution of the calcitonin/DH31 pNP family. (A) Truncated multiple sequence alignment of Platynereis DH31 with arthropod DH31 pNPs, all lacking cysteine residues. (B) Truncated multiple sequence alignment of Platynereis calcitonin with other lophotrochozoan and deuterostome calcitonin pNPs, all containing two conserved Cys residues. (C) Scenario of gene duplications and losses to account for the present distribution of calcitonin and DH31 pNPs in bilaterians.

Conzelmann et al. BMC Genomics 2013 14:906   doi:10.1186/1471-2164-14-906
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