Table 5

Kinases with common targets encoded by the EGF-, EphrinAs- and SP600125-regulated genes
Kinase EGF 1&4 h UP SP 1&4 h DN EFNAs DN
MAPK1 2.51E-07 1 1.22E-02
SRC 5.21E-06 1 1
MAPK14 1.36E-05 1 1.88E-04
EGFR 1.39E-05 1 1
INSR 1.02E-04 1 1
MAPK3 1.70E-04 1 5.05E-02
JAK2 3.57E-04 1 1
ROCK1 2.62E-03 1 1
JAK1 3.30E-03 1 1
PTK2 3.62E-03 1 1
MAPK8 2.92E-02 1 1
PRKCQ 4.00E-02 1 1
ERBB2 5.35E-02 1 1
FYN 5.36E-02 1 1
JAK3 5.45E-02 1 1
IGF1R 7.63E-02 1 1
PRKCD 9.07E-02 1 1
EGF 24&48 h DN SP 24&48 h UP EFNAs UP
CDK2 5.84E-03 1.43E-04 1
CDC2 1.21E-02 2.45E-06 1

UP denotes induced, DN suppressed genes. All kinases with p-values better than 0.1 for the EGF-regulated targets are listed. No kinases common to all three agents were identified.

Blumenberg

Blumenberg BMC Genomics 2013 14:85   doi:10.1186/1471-2164-14-85

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