Table 3

Fold change differences in gene expression in M. bovis field isolates 1121, 2451 and 1307 compared to 2122
Mb CDS Mtb CDS Common 1121/01 2451/01 1307/01 Product Assoc. SNP/InDel
7h9 RPMI 4hr MØ 24 hr MØ 7h9 RPMI 4hr MØ 24 hr MØ 7h9 RPMI 4hr MØ 24 hr MØ
Mb0038c Rv0037c 4↑ 3↑ 3↑ probable conserved integral membrane protein
Mb0124c Rv0120c fusA2 3↑ 3↑ probable elongation factor
Mb0258 Rv0252 nirB 9↑ 12↑ 21↑ 9↑ nitrite reductase (large subunit) sSNP at postn. 303227 in 1307/01 only; C-T;
Mb0259 Rv0253 nirD 3↑ 4↑ 5↑ nitrite reductase (small subunit)
Mb0428c Rv0420c 2↑ possible transmembrane protein
Mb0734 Rv0713 2↑ probable conserved transmembrane protein
Mb0947c Rv0923c 2↓ 2↓ conserved hypotheitical protein
Mb0948c Rv0924c mntH cation uptake system
Mb1013; Mb1014 Rv0987 5↑ 10↑ 5↑ 5↑ 7↑ 6↑ probable adhesion component transport ABC transporter nSNP at postn. 1104263 in 2451/01 and 1307/01; A-G (STOP to W); sSNP at postn 1103991 in 2451/01 and 1307/01
Mb1015 Rv0988 3↑ 9↑ 3↑ 5↑ 5↑ possible conserved exported protein
Mb1161 Rv1130 2↓ conserved hypothetical protein
Mb1162 Rv1131 gltA1 3↓ probable citrate synthase
Mb1554c Rv1527c pks5 2↓ probable polyketide synthase
Mb1562 Rv1535 2↑ 5↑ hypothetical protein
Mb1619c Rv1593c 2↑ conserved hypothetical protein
Mb1749c Rv1720c 10↑ 19↑ 18↑ 12↑ conserved hypothetical protein nSNP at postn. 1932704 in 1307/01 only ; C-T (G to D)
Mb1750c Rv1721c 6↑ 3↑ 9↑ 5↑ conserved hypothetical protein
Mb1833c Rv1804 3↓ conserved hypothetical protein
Mb1834c Rv1805c 4↑ hypothetical protein
Mb1835 Rv1806 PE20 3↑ PE family protein
Mb1885c Rv1854c ndh 3↓ probable nadh dehydrogenase
Mb1914c Rv1882c 6↑ 3↑ 6↑ probable short-chain type dehydrogenase/reductase sSNP at postn 2122970 in 2415/01 only: C-T
Mb2007c Rv1985c 4↑ 3↑ 3↑ probable transcriptional regulatory protein nSNP at postn. 2208296 in 1307/01 only; G-A (Q to Stop)
Mb2015c RV1992c ctpG 2↓ 3↓ probable cation transporter
Mb2420c Rv2398c cysW 2↓ 6↓ sulphate transporter
Mb2421c Rv2399c cysT 2↓ 4↓ sulphate transporter
Mb2607 Rv2577 9↓ 5↓ 7↓ 12↓ 10↓ 7↓ 7↓ 13↓ conserved hypothetical protein [first part]
Mb3194 Rv3169 3↑ 3↑ 2↑ 3↑ conserved hypothetical protein
Mb3477c Rv3447c 8↓ 3↓ 10↓ 9↓ 2↓ 7↓ probable conserved membrane protein nSNP at postn. 3812465 in 2451/01 and 1307/01; T-C (S to G)
Mb3563c Rv3533c PPE62 5↑ 5↑ ppe family protein
Mb3721c Rv3696c glpK 3↓ glycerol kinase
Mb3803 Rv3774 echA21 8↑ 7↑ 22↑ possible enoyl-coA hydratase sSNP at postn. 4155803 in 2415/01 only; G-A

Up and down arrows indicate fold up- and downregulation, respectively, and empty cells indicate no change in expression.

Golby et al.

Golby et al. BMC Genomics 2013 14:710   doi:10.1186/1471-2164-14-710

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