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Open Access Highly Accessed Research article

Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

James R Doroghazi1* and William W Metcalf12

Author Affiliations

1 Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA

2 Department of Microbiology, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA

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BMC Genomics 2013, 14:611  doi:10.1186/1471-2164-14-611

Published: 11 September 2013

Additional files

Additional file 1:

A stand-alone website showing all natural product gene clusters analyzed in this study, along with separate files for conserved clusters mentioned in the text and pHMM files. Use of the HTML files requires Javascript. Homologous genes are shown in the same color. All homologous genes on a page are highlighted upon mouseover of any of them. Mouseover also produces a description containing the locus tag and annotation for each gene. Mouseover for a domain box above the gene arrows shows the domain name. Clicking on a gene arrow produces a page with the amino acid sequence and a link to BLAST the nr protein database.

Format: ZIP Size: 6.7MB Download file

Open Data

Additional file 2:

A NeighborNet analysis on concatenated ribosomal proteins.

Format: PDF Size: 23KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

List of genes grouped together within the genera of interest, gene range is separated by commas and gene groups are separated by semicolons.

Format: DOCX Size: 16KB Download file

Open Data