Table 2

Annotated probe sets with a significant effect for artery and age x artery interaction
Probe Set ID Gene Symbol Gene Description Bits1 E-value2 Effect for age FDR3 Effect for artery FDR3 Interaction effect FDR3 1 year contrast FDR3 2 year contrast FDR3 Human ortholog Heatmap cluster
Ssc.14126.1.A1_at FAM65B5 Homo sapiens family with sequence similarity 65, member B 238 0 0.07 0.01 0.03 0.01 0.55 FAM65B A
Ssc.15285.1.S1_at TPPP5 Bos taurus tubulin polymerization promoting protein 186 1.00E-44 0.69 0 0.02 0 0.09 TPPP A
Ssc.31132.1.A1_at TRAF3IP25 Bos taurus TRAF3 interacting protein 2 1370 0 0.91 0.04 0.03 0.01 0.98 TRAF3IP2 A
Ssc.5052.1.S1_at FKBP155 Homo sapiens FK506 binding protein 15 2159 0 0.32 0.02 0.04 0.72 0.02 FKBP15 A
Ssc.15541.1.A1_at PAMR15 Bos taurus regeneration associated muscle protease 1929 0 0.41 0.02 0.04 0.01 0.68 PAMR1 B
Ssc.16614.1.A1_at PPP1R12A4 Protein phosphatase 1 regulatory subunit 12A 0.07 0.01 0.04 0.4 0.01 PPP1R12A B
Ssc.21536.2.S1_at PDE5A6 Homo sapiens phosphodiesterase 5A, cGMP-specific 282 2.00E-64 0.36 0 0.05 0.03 0 PDE5A B
Ssc.21845.1.S1_at OPHN14 Oligophrenin 1 0.91 0.04 0.04 0.98 0.02 OPHN1 B
Ssc.10497.1.S1_at SCUBE36 signal peptide, CUB domain, EGF-like 3 526 8.00E-146 0.2 0.03 0.04 0.01 0.96 SCUBE3 C
Ssc.15046.1.A1_at NCOA75 Bos taurus nuclear receptor coactivator 7 498 0 0.12 0.01 0.05 0.01 0.36 NCOA7 C
Ssc.17488.1.S1_at PAN34 poly(A) specific ribonuclease subunit homolog 0.02 0.01 0.02 0.43 0.01 PAN3 C
Ssc.21735.1.S1_s_at NPHP15 Bos taurus nephronophthisis 1 615 0 0.31 0.01 0.03 0.66 0.01 NPHP1 C
Ssc.8097.1.A1_at RAB185 RAB18, member RAS oncogene family 322 2.00E-84 0.1 0.01 0.01 0 0.83 RAB18 C
Ssc.1205.1.S1_at NR2F25 Macaca mulatta nuclear receptor subfamily 2, group F, member 2, transcript variant 2 438 0 0.34 0.03 0.05 0.01 0.9 NR2F2 D
Ssc.21644.1.S1_at STT3A5 PREDICTED: Pan troglodytes integral membrane protein 1, transcript variant 3 98 9.00E-18 0.44 0.03 0.03 0.01 0.99 SST3A D
Ssc.9029.1.S1_at CST35 Homo sapiens cystatin C 153 3.00E-34 0.16 0.05 0.01 0.3 0.01 CST3 D
Ssc.17115.1.A1_at TMEM435 Bos taurus transmembrane protein 43 1403 0 0.68 0.01 0.03 0 0.39 TMEM43 E
Ssc.19358.1.S1_at ZDHHC95 Homo sapiens zinc finger, DHHC-type containing 9 1834 0 0.31 0.04 0.05 0.95 0.03 ZDHHC9 E
Ssc.5605.1.A1_at ITPR14 Inositol 1,4,5-trisphosphate receptor type 1 0.34 0.04 0.02 0.54 0.02 ITPR1 E
Ssc.1362.1.S1_at DBNL5 Bos taurus drebrin-like 785 0 0.29 0.02 0.03 0.91 0.01 DBNL F
Ssc.16682.1.S1_at RRP1B6 Homo sapiens ribosomal RNA processing 1 homolog B 394 9.00E-95 0.69 0.05 0.05 0.99 0.03 RRP1B F
Ssc.27980.1.A1_at FAM70A5 Homo sapiens family with sequence similarity 70, member A 579 0 0.07 0.01 0.03 0.37 0.01 FAM70A F
Ssc.29681.1.A1_at CCDC486 Bos taurus coiled-coil domain containing 48 68 1.00E-06 0.43 0.02 0.05 0.01 0.65 CCDC48 F
Ssc.3348.1.S1_at CD975 Homo sapiens CD97 molecule 517 0 0.02 0 0.05 0 0.04 CD97 F
Ssc.4643.1.A1_at NR4A25 Homo sapiens nuclear receptor subfamily 4, group A, member 2 400 0 0.03 0.02 0.05 0.01 0.77 NR4A2 F
Ssc.5113.2.A1_at RPE5 Bos taurus ribulose-5-phosphate-3-epimerase 204 0 0.41 0 0.04 0.01 0 RPE F
Ssc.6463.1.A1_at MYD885 Homo sapiens myeloid differentiation primary response gene 658 0 0.2 0.03 0.04 0.95 0.02 MYD88 F
Ssc.10406.1.A1_at THBS14 Thrombospondin 1 precursor 0.13 0 0.03 0 0.04 THBS1 G
Ssc.13002.1.S1_at PPP1R14A5 Sus scrofa protein phosphatase 1, regulatory (inhibitor) subunit 14A 521 0 0.61 0.05 0.05 0.99 0.03 PPP1R14A G
Ssc.1509.1.S1_at TNFRSF216 Bos taurus tumor necrosis factor receptor superfamily, member 21 1199 0 0.36 0.05 0.04 0.02 0.97 TNFRSF21 G
Ssc.17903.1.A1_at ACYP14 Acylphosphatase, organ-common type isozyme 0.71 0.01 0.04 0 0.17 ACYP1 G
Ssc.22406.1.A1_at AQP15 Bos taurus aquaporin 1 1211 0 0.27 0.01 0.05 0.01 0.46 AQP1 G
Ssc.4707.1.A1_at KITLG5 Homo sapiens KIT ligand 161 1.00E-36 0.16 0.03 0.03 0.01 0.99 KITLG G
Ssc.5844.1.A1_at PTCD35 Homo sapiens Pentatricopeptide repeat domain 3 1600 0 0.06 0.04 0.02 0.01 0.6 PTCD3 G
Ssc.6788.1.A1_at SORBS26 Homo sapiens sorbin and SH3 domain containing 2 452 1.00E-123 0.34 0.02 0.04 0.01 0.59 SORBS2 G
Ssc.8683.1.S1_at PLN5 Bos taurus phospholamban 129 5.00E-27 0.17 0 0.03 0.02 0 PLN G
Ssc.9527.1.S1_at NPNT5 Homo sapiens nephronectin 1017 0 0.28 0.01 0.03 0 0.28 NPNT G
Ssc.9714.2.S1_at LMO44 Bos taurus LIM domain only 4 747 0 0.61 0.01 0.05 0 0.19 LMO4 G
Ssc.17370.1.A1_at ADRA1B5 Homo sapiens adrenergic, alpha-1B-, receptor 133 2.00E-28 0.14 0 0.05 0 0.01 ADRA1B H
Ssc.20476.1.S1_at CR1L4 Complement C4b binding protein CR-1 like 0.41 0.01 0.04 0 0.15 CR1L H
Ssc.26444.1.A1_at FARP16 Bos taurus FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 533 5.00E-148 0.09 0.01 0.05 0.01 0.34 FARP1 H
Ssc.3034.1.S1_at SCAMP25 Homo sapiens secretory carrier membrane protein 2 1231 0 0.55 0.02 0.02 0.93 0.01 SCAMP2 H
Ssc.4216.1.S1_at RNPEP5 Homo sapiens arginyl aminopeptidase 1451 0 0.26 0.04 0.04 0.92 0.03 RNPEP H
Ssc.8492.1.A1_at RIMS24 Regulating synaptic membrane exocytosis protein 2 0.94 0.05 0.03 0.01 0.84 RIMS2 H
Ssc.13576.1.S1_at IFT575 Bos taurus intraflagellar transport 57 homolog 1982 0 0.09 0.02 0.02 0.89 0.01 ITF57 I
Ssc.24231.1.S1_at CBL5 Homo sapiens Cas-Br-M (murine) ecotropic retroviral transforming sequence 204 0 0.87 0.02 0.05 0.69 0.02 CBL I
Ssc.29996.1.A1_at DPP104 dipeptidylpeptidase 10 isoform1 0.68 0.01 0.02 0.72 0.01 DPP10 I
Ssc.23484.1.A1_a_at SCARB25 Bos taurus scavenger receptor class B, member 2 141 7.00E-31 0.08 0.05 0.04 0.01 0.93 SCARB2 J
Ssc.24920.2.S1_a_at DUS2L5 Bos taurus dihydrouridine synthase 2-like, SMM1 homolog 1528 0 0.12 0.02 0.04 0.57 0.01 DUS2L J
Ssc.5587.1.A1_at NID15 Homo sapiens nidogen 1 262 0 0.86 0 0.01 0.29 0 NID1 J
Ssc.21655.1.A1_at GDNF5 Mus musculus glial cell line derived neurotrophic factor 202 0 0.11 0 0.03 0 0.1 GDNF K
Ssc.9436.1.A1_at SETBP15 Homo sapiens SET binding protein 1 232 0 0.06 0 0.02 0 0.14 SETBP1 K
Ssc.10966.1.A1_at RBBP74 Histone acetyltransferase type B subunit 2 0.54 0 0.03 0.06 0 RBBP7 L
Ssc.23899.1.A1_at MKX5 Homo sapiens mohawk homeobox 400 0 0.77 0 0.02 0 0.13 MKX L
Ssc.8790.1.A1_at CCL284 Small inducible cytokine A28 precursor 0.52 0.03 0.03 0.95 0.02 CCL28 L
Ssc.14335.1.A1_at SH2D4B4 SH2 domain containing 4B 0.9 0.01 0.02 0.72 0.01 SH2D4B M

1Bit score provides a measure of the quality of the alignment. 2Number of hits one can “expect” to see by chance when searching a database of a particular size 3False discovery rate. 4Annotation from AffymetrixNetAffx.5Annotation from ANEXdb: Animal Expression Database. 6Human ortholog from NCBI BLASTn.

Bahls et al.

Bahls et al. BMC Genomics 2013 14:443   doi:10.1186/1471-2164-14-443

Open Data