Table 2

Significantly overrepresented functional annotations describing sleep-repressed transcripts in the lung
Cluster 1
Category Term P-Value Fold Enrichment FDR(%)
SP_PIR_KEYWORDS Chaperone 4.07E-15 10.133 5.40E-12
SP_PIR_KEYWORDS Stress response 4.51E-14 21.351 5.94E-11
SP_PIR_KEYWORDS Molecular chaperone 4.92E-12 44.118 6.46E-09
GOTERM_BP_FAT GO:0006457 Protein folding 7.28E-11 8.835 1.18E-07
Cluster 2
Category Term P-Value Fold Enrichment FDR(%)
SP_PIR_KEYWORDS Molecular chaperone 4.92E-12 44.118 6.46E-09
SP_PIR_KEYWORDS Stress-induced protein 0.001235 51.471 1.611722
SP_PIR_KEYWORDS Heat shock 0.001235 51.47 1.611722
Cluster 3
Category Term P-Value Fold Enrichment FDR(%)
SP_PIR_KEYWORDS Isomerase 0.00167 4.65 2.18
Cluster 4
Category Term P-Value Fold Enrichment FDR(%)
KEGG_PATHWAY NOD-like receptor signaling pathway 2.78E-04 7.537 0.30520
Cluster 5
Category Term P-Value Fold Enrichment FDR(%)
KEGG_PATHWAY Antigen processing and presentation 3.99E-05 6.840 0.04383

Sleep repressed transcripts demonstrate both significantly reduced expression in sleep as compared to sleep deprivation (FDR < 1%) and a decreasing expression as spontaneous sleep progresses (FDR <1%). Overrepresented functional annotations describing this group of transcripts that met a FDR cutoff of 5% are shown. Clusters describe overlapping gene annotations as determined by the DAVID functional clustering feature.

SP_PIR: Swiss-Prot Protein Information Resource; GOTERM_BP_FAT: Gene ontology term Biological process; KEEG: Kyoto Encyclopedia of Genes and Genomes.

Anafi et al.

Anafi et al. BMC Genomics 2013 14:362   doi:10.1186/1471-2164-14-362

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