Transcript profiles of sleep repressed genes involved in the unfolded protein response. Temporal profiles of expression for select sleep responsive genes with annotations relating to protein processing and endoplasmic reticulum (ER) stress. Changes in gene expression from the baseline condition (lights on) are plotted as a percent of baseline expression levels. Maroon curves show data from experimentally sleep deprived animals and blue curves show data from spontaneously sleeping animals. Data from heart tissue is connected with dashed lines. Data from lung tissue is connected by uninterrupted lines. All genes shown here met statistical criteria for sleep specific repression in both tissues. Data shown represents mean ± standard error for 8 or 9 biological replicates.
Anafi et al. BMC Genomics 2013 14:362 doi:10.1186/1471-2164-14-362