Variation in expression conservation of genes of different functional groups under different perturbations. The LNS for each gene for matched datasets of the two species was calculated. LNS scores were first k-means clustered and then arranged hierarchically by the centers of these clusters, and the scores presented by a heat map. GO biological process enrichment for each cluster was determined. Enriched terms with a Bonferonni-corrected p value lower than 0.01 are labeled. The expression patterns of ribosome-related genes are conserved upon most perturbations. However, the expression of many of the genes of other functions is only conserved under specific conditions. The range of LNS scores varies for different datasets. Datasets with large magnitude expression changes tend to have a greater LNS range; dataset size and quality also influence the range of LNS.
Guan et al. BMC Genomics 2013 14:33 doi:10.1186/1471-2164-14-33