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Open Access Highly Accessed Research article

Genome-wide association study of sleep in Drosophila melanogaster

Susan T Harbison12*, Lenovia J McCoy1 and Trudy FC Mackay1

Author Affiliations

1 Department of Genetics, North Carolina State University, Raleigh, North Carolina, 27695, USA

2 Present address: Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Dr. MSC 1654, Building 10, Room 7D13, Bethesda, MD, 20892, USA

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BMC Genomics 2013, 14:281  doi:10.1186/1471-2164-14-281

Published: 25 April 2013

Additional files

Additional file 1:

Quantitative genetic analyses of variance of mean and CVE sleep phenotypes in the DGRP lines.

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Additional file 2:

Histograms of mean and coefficient of environmental variation (CVE) for bout number, average bout length, and waking activity.

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Additional file 3:

Mean phenotypic values of sleep quantitative traits.

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Additional file 4:

Distribution of significant SNPs by site class.

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Additional file 5:

Q-Q plots for males.

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Additional file 6:

Q-Q plots for females.

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Additional file 7:

P-value histograms for males.

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Additional file 8:

P-value histograms for females.

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Additional file 9:

GWA results for mean sleep traits.

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Additional file 10:

GWA results for sleep traitCVEs.

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Additional file 11:

Minor allele frequency versus normalized effect size.

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Additional file 12:

Additive multiple SNP predictive model results.

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Additional file 13:

Summary characteristics of genes implicated in the GWAS.

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Additional file 14:

Gene Ontology (GO) categories.

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Additional file 15:

Genes interacting with Epidermal growth factor receptor (Egfr) pathway.

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Additional file 16:

Mutant and RNAi verification test results.

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Additional file 17:

Pleiotropic effects in sleep candidate genes.

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