The CU-DREAM extension program. (A) A flow chart illustrating how the microarray data were processed. First, the microarray data for the fields of interest were collected and prepared. The program then computed the status of each gene (upregulated or downregulated) using Student’s t-test. Subsequently, the assessed genes were compared with a list of genes containing intragenic L1s. The results showed the associations between the gene regulation status and the presence of an L1 sequence in terms of ORs and p-values. (B) A table indicating the intersection between each experimental result and the genes containing intragenic L1s. These intersections are referred to as groups A through D. Group A includes the genes that are upregulated or downregulated and contain intragenic L1s. Group B includes the genes that are not upregulated or downregulated but contain intragenic L1s. Group C includes the genes that are upregulated or downregulated but do not contain intragenic L1s. Group D includes the remaining genes, which are not upregulated or downregulated and do not contain intragenic L1s.
Wanichnopparat et al. BMC Genomics 2013 14:205 doi:10.1186/1471-2164-14-205