Table 1

miRNAs and putative target genes
MiRNA Conserved targets Gene name Number of 3-UTR conserved site Gene rank on basis of total context score
miR-27b 1106 IGF1 1 1089
NFATc1 1 224
MEF2C 1 885
GSK3b 1 905
TEAD1 3 420
MSTN 1 82
miR-132 389 PPP3CA 1 383
GSK3b 1 374
miR-186 777 IGF1 1 508
IGF1R 2 349
miR-199b-5p 460 GSK3b 2 103

TargetScan predicts biological targets of miRNAs by searching for the presence of conserved 8mer and 7mer sites that match the seed region of each miRNA. In mammals, predictions are ranked based on the predicted efficacy of targeting as calculated using the context scores of the sites. The context score is the sum of the contribution of these four features: site-type contribution; 3 pairing contribution; local AU contribution; position contribution.

Miretti et al.

Miretti et al. BMC Genomics 2013 14:194   doi:10.1186/1471-2164-14-194

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