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Open Access Highly Accessed Open Badges Research article

Dynamic regulation of epigenomic landscapes during hematopoiesis

Brian J Abraham12, Kairong Cui1, Qingsong Tang1 and Keji Zhao1*

Author Affiliations

1 Systems Biology Center, NHLBI, NIH, Rockville Pike, Bethesda, MD, USA

2 Bioinformatics Program, Boston University, Boston, MA, USA

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BMC Genomics 2013, 14:193  doi:10.1186/1471-2164-14-193

Published: 19 March 2013

Additional files

Additional file 1:

Methods. Figure S1A-S1D: Expression of type-specific genes in four cell types – related to Figure 1. Figure S2A-S2D. Type-specific genes are enriched in functional pathways – related to Figure 1. Figure S3A-S3B. Enrichment of H3K27me3 at HOXA and HOXB loci – related to Figure 3. Figure S4. Bivalency of promoters across multiple cell types with examples – related to Figure 3. Figure S5A-B. Density of chromatin proteins at Gata3 and Pax5 genes – related to Figure 4. Figure S6. Resolution and preparation of transcription factor genes bivalent in HSPC – related to Figure 3. Table S1. Excel document of lists of type-specific genes. Table S2. Known enhancers and their enrichments in H3K4me1 and/or H2A.Z in four cell types. Table S3. Files used in analysis and their sources. Table S4. Mapped sequencing reads, unique reads, and unique reads in enriched islands. Discussion of Figure7B.

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