Fold change differences between DEGs of the short- and the longer-lived N. furzeri strains. A scatterplot of fold changes (log-transformed) in the short-lived strain GRZ and the longer-lived strain MZM403 is shown. The 43 DEGs in skin are given in blue, and the 43 DEGs in brain in red. In (A), fold changes are shown as determined over the time span of 9 and 26 weeks for GRZ and MZM-0403, respectively. In (B), MZM-0403 fold changes were normalised to the GRZ time span of 9 weeks. P-values are calculated to test for differences in fold changes between GRZ and MZM-0403 using two-sample, paired Wilcoxon test. In contrast to standard fold changes (A), time-normalised fold changes (B) were significantly different between GRZ and MZM-0403 in skin and brain.
Petzold et al. BMC Genomics 2013 14:185 doi:10.1186/1471-2164-14-185