The kinetic model of the protein interactome evolution. a. Schematic representation of proteome formation. b. Schematic representation of interactome formation. The symbols X and Y indicate the protein class. Other symbols indicate rates: f0 - protein origination, ki - protein inactivation, kXY and kYX - protein transition between classes, k2 - protein duplication, f0ξ0/N - emergence of an interaction with a newborn protein, μ emergence of an interaction with an existing protein, Δμ- preference and r – loss of interaction.
Pawlowski et al. BMC Genomics 2013 14:172 doi:10.1186/1471-2164-14-172