Open Access Highly Accessed Research article

Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans

Yuru Zhang1, Xiaoju Zou2, Yihong Ding1, Haizhen Wang1, Xiaoyun Wu1 and Bin Liang1*

Author Affiliations

1 Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiao-Chang Dong Road, Kunming, Yunnan 650223, China

2 Department of Life Science and Biotechnology, Kunming University, Kunming 650214, China

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BMC Genomics 2013, 14:164  doi:10.1186/1471-2164-14-164

Published: 12 March 2013

Additional files

Additional file 1: Table S1:

C. elegans lipid metabolic gene database. 471 lipid metabolism genes were retrieved from the C. elegans genome. Different colors were used to highlight the origin of the various lipid genes. The metabolism pathways of each gene mainly come from the KEGG database.

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Additional file 2: Figure S1:

Annotation of biological processes of 471 C. elegans lipid metabolism genes using ClueGO. The chart displays part of significant enrichment analysis of Gene Ontology molecular function in C. elegans lipid metabolic gene database. The x axis stands for the amount molecular function terms in Gene Ontology. One star denotes P < 0.05, while two stars denote P < 0.01.

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Additional file 3: Table S2:

Lipid metabolism genes in 5 model organisms. All genes IDs were unified as Ensembl gene ID. Respectively, 581, 585, 563, and 428 lipid metabolic genes were present in the human, mouse, rat, and Drosophila genomes.

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Additional file 4: Figure S2:

The list of human, mouse, rat, and Drosophila lipid metabolic genes. 581 (A), 585 (B), 563 (C), and 428 (D) lipid metabolism genes present in human, mouse, rat, and Drosophila genome, respectively. Abbreviation: CEL- C. elegans; DRO- Drosophila.

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Additional file 5: Table S3:

Lipid metabolism genes related to human metabolic diseases in humans, C. elegans, mice, rats, and Drosophila. Respectively, 97, 94, 128, 107, and 97 lipid genes were overlapped with metabolic diseases in human, C. elegans, mouse, rat, and Drosophila.

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