Open Access Research article

Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity

John F Bowyer1*, Tucker A Patterson1, Upasana T Saini1, Joseph P Hanig4, Monzy Thomas1, Luísa Camacho2, Nysia I George3 and James J Chen3

Author Affiliations

1 Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-9502, USA

2 Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079-9502, USA

3 Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079-9502, USA

4 Center for Drug Evaluation and Research, U.S. Food & Drug Administration, Silver Spring, MD, 20993, USA

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BMC Genomics 2013, 14:147  doi:10.1186/1471-2164-14-147

Published: 5 March 2013

Additional files

Additional file 1: Table S1:

Normalized gene expression in control animals for all four brain regions retermined by the Agilent-014879 Whole Rat Genome 4x44K 60mer oligonucleotide arrays (G4131F, Agilent Technologies, Palo Alto, CA; NCBI GEO Accession # GPL7294).

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Additional file 2: Table S2:

Putative function of genes with a 15-fold* or more increased expression in MAV compared to striatum and parietal cortex under control conditions.

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Additional file 3: Table S3:

MAV genes significantly affected at 3 hr after EIH or AMPH exposure relative to control or relative to each other.

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Additional file 4: Table S4:

Normalized choroid plexus expression of all genes at 3 hr after saline (control), AMPH or EIH.

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Additional file 5: Table S5:

Sequences of the oligonucleotides used for the gene expression analysis by quantitative RT-PCR (FWD: forward; RV: reverse).

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