Open Access Research article

The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection

Mark N Ragheb1, Christopher B Ford1, Michael R Chase1, Philana Ling Lin2, JoAnne L Flynn3 and Sarah M Fortune145*

Author Affiliations

1 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA

2 Department of Pediatrics, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA

3 Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

4 Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA

5 Broad Institute of MIT and Harvard, Cambridge, MA, USA

For all author emails, please log on.

BMC Genomics 2013, 14:145  doi:10.1186/1471-2164-14-145

Published: 5 March 2013

Additional files

Additional file 1: Figure 1:

Comparison of mate pair distance distribution from reads mapped to H37Rv versus single copy MIRU genome. (a) The distribution of mate pair distances from each sequencing read spanning the 3192 MIRU locus (+/− 100 bp) for strain G-2, for reads mapped to the H37Rv genome. (b) The distribution of mate pair distances from each sequencing read (for same strain and locus as (a)), for reads mapped to the single copy MIRU genome. For both (a) and (b), the bin size is set to 100. Bars in blue represent all MIRU sequencing reads +/− 100 bp while bars overlaid in green represent only the MIRU sequencing reads.

Format: PDF Size: 119KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data