Additional file 1: Figure S1.

miRNA profiling in MCF7 cells, MCF7-derived mammospheres (MMO), and differentiated mammospheres (DIFF MMO). miRNA profiling was performed using an oligonucleotide array. A. Unsupervised cluster analysis and heat-map including all probes. Clustering of all mammosphere samples indicate a defined profile, distinct from MCF7 and DIFF MMO. B. Volcano plots of fold change (represented in Log2 ratio in the x axis) vs. P value (represented in Log10 ratio in the y axis). Volcano plots indicate a subset of miRNAs downregulated in MMO, respective to MCF7 and DIFF MMO. For comparison, MCF7 and DIFF MMO (in the lower panel) display a very similar profile.

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Ouzounova et al. BMC Genomics 2013 14:139   doi:10.1186/1471-2164-14-139