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Open Access Highly Accessed Methodology article

Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing

Junwen Wang, Yudong Xia, Lili Li, Desheng Gong, Yu Yao, Huijuan Luo, Hanlin Lu, Na Yi, Honglong Wu, Xiuqing Zhang, Qian Tao* and Fei Gao*

BMC Genomics 2013, 14:11  doi:10.1186/1471-2164-14-11

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