Additional file 4.

Correlation between changes in gene expression and changes in promoter mark H3K4me3. (A) Genome-wide association between changes in gene expression (>2-fold, p<0.05) and changes in H3K4me3 (>2-fold in at least 3 out of 4 donors) during 7 days of differentiation. (B) GO term analysis of all genes where H3K4me3 changed >2-fold in 3 out of 4 donors. A cluster analysis using DAVID was performed, and one typical term per cluster is shown. (C) Counts of genes in the different expression clusters for all dynamic H3K4me3 regions and the 500 regions which changed the most in H3K4me3 (up or down) during one week of chondrogenesis. (D) GO term analysis for genes within the top 500 regions which increased or decreased in H3K4me3, but failed to reach a >2-fold expression change. DAVID analysis was performed, and one typical term per cluster is shown.

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Herlofsen et al. BMC Genomics 2013 14:105   doi:10.1186/1471-2164-14-105