Additional file 3: Table S1.

Functional annotation enrichment in biclusters associated with low risk of relapse and in biclusters associated with high risk of relapse. Table S2. Differentially expressed genes between Bicluster 7 and Bicluster 21. Genes are ranked in ascending order of p-values reported from two-sample t-test, and the related statistics scores of each gene, including t-scores, p-values, False Discovery Rate (FDR), q-values and Benjamini-Hochberg (BH) adjusted FDR are summarized. Table S3. Enrichment analysis of differentially expressed genes between Bicluster 7 and Bicluster 21 determined by GeneSetDB at the significance level < 0.001. Table S4. Gene Classifiers determined by PAM – the maximum number of probe sets which can accurately characterise Bicluster 7 and Bicluster 21. The highlighted genes overlap with the OncotypeDx commercial gene list. Table S5. Multivariate analyses of prognostic importance of biclusters in comparison to conventional clinical factors, molecular tumour subtypes, and genetic grade. Significance of biclustered classification for prognosis was compared to chance by randomly assigned tumours into 44 arbitrary groups and estimating the association between membership of these arbitrary groups and DFS. Univariate Cox PH analysis revealed no statistically significant association between arbitrary group membership and survival outcome. Significance is indicated in the ranges: 0 ≤ 0.001 ‘***’; 0.001 ≤ 0.01 ‘**’; 0.01 ≤ 0.05 ‘*’; 0.05 ≤ 0.1 ‘.’; 0.1 ≤ 1 ‘-’. Table S6. Summary of clinical information of 437 non-adjuvant treated patients.

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Wang et al. BMC Genomics 2013 14:102   doi:10.1186/1471-2164-14-102