Evaluation of functional enrichment measures and their combinations. Distributions of (A) functional homogeneity index (or average IC value) and (B) semantic similarity (or average all pair-wise Resnik's similarity) are exhibited for significantly enriched GO BP terms in the 'breast/up-regulated miRNA cluster' from Volinia et al. (see index 1 in Supplement Table S2) by applying target variation #6 in Table 1. MicroRNA-centric measure (μ) outperforms the traditional target gene-centric measure (ρ) and others.
Lee et al. BMC Genomics 2012 13(Suppl 7):S17 doi:10.1186/1471-2164-13-S7-S17