Table 5

HPD gene set overlapping cluster membership

Pathway Name, (enrichment p-value)

HPD similarity grouping

de novo Gene Membership

de novo Gene Ontology

de novo Protein Interactants

Weighted Consolidation

Enrichment Consolidation


Aurora B signaling (p = 1.32 × 10-2)



Aurora A signaling (p = 1.39 × 10-4)

Signaling by Aurora kinases (p = 3.27 × 10-4)



FOXA transcription factor networks (p = 2.23 × 10-4)

FOXA1 transcription factor network (p = 6.53 × 10-5)


FOXA2 and FOXA3 transcription factor networks (p = 1.38 × 10-2)


Fanconi Anemia pathway (p = 8.36 × 10-3)


ATRBRCA_PATHWAY (p = 6.75 × 10-3)



ATM mediated phosphorylation of repair proteins (p = 1.93 × 10-3)

Recruitment of repair and signaling proteins to double-strand breaks (p = 2.58 × 10-3)


Note: p-values are derived from one-tail Fisher's Exact test, before multiple test correction. Dividers and matching symbols indicate pathways groups within a consolidation method.

Doderer et al. BMC Genomics 2012 13(Suppl 6):S18   doi:10.1186/1471-2164-13-S6-S18

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