Network cases for Type II recruitment analysis in context of Drosophila melanogaster development. Case I) Recruitment of Type II is overlooked here and it imitates the simplified model used in previous studies. In this type of network, BMP:Type I complex (BR1) acts as the sole signaling complex. Case II) Upon the formation of a BMP: Type I complex, subsequent recruitment of Type II receptor is considered here. But a direct interaction between BMP and Type II receptor doesn't happen in the network. Here, a tripartite complex BMP:Type I:Type II (BR1R2) activates the downstream pathways. Case III) Similar to Case II, but with an exception that a direct interaction between BMP and Type II receptor is allowed to form a BMP:Type II complex (BR2) by changing BR1 to BR2. The kinetic equations are equivalent to the SBP system investigated in .
Karim et al. BMC Genomics 2012 13(Suppl 6):S10 doi:10.1186/1471-2164-13-S6-S10