Domain peaks derived from genes with low mutation frequencies Depiction of the gene and domain landscape topographies corresponding to an instance where the individual genes contributing mutations to a shared domain do not achieve significance, yet the shared domain aggregates enough mutations to achieve significance. Top map – arrows point to genes with non-significant mutation frequencies. Bottom map – domain peak aggregates enough mutations to be significant.
Nehrt et al. BMC Genomics 2012 13(Suppl 4):S9 doi:10.1186/1471-2164-13-S4-S9