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This article is part of the supplement: SNP-SIG 2011: Identification and annotation of SNPs in the context of structure, function and disease

Open Access Highly Accessed Proceedings

Domain landscapes of somatic mutations in cancer

Nathan L Nehrt12, Thomas A Peterson1, DoHwan Park3 and Maricel G Kann1*

  • * Corresponding author: Maricel G Kann mkann@umbc.edu

  • † Equal contributors

Author Affiliations

1 Department of BiologicalSciences, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA

2 Division of Imaging and Applied Mathematics, OSEL, CDRH, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA

3 Department of Mathematics and Statistics, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA

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BMC Genomics 2012, 13(Suppl 4):S9  doi:10.1186/1471-2164-13-S4-S9

Published: 18 June 2012

Additional files

Additional file 1:

Contains supplementary tables S1 to S7 Table S1 – Mutation counts for breast cancer Table S2 – Shared significantly mutated genes in colon and breast cancer Table S3 – Shared significantly mutated domains in colon and breast cancer Table S4 – GO terms enriched in domains significantly mutated in colon cancer Table S5 - GO terms enriched in domains significantly mutated in breast cancer Table S6 – GO terms enriched in genes significantly mutated in colon cancer Table S7 - GO terms enriched in genes significantly mutated in breast cancer

Format: DOCX Size: 30KB Download file

Open Data

Additional file 2:

Top genes highly mutated in colon cancer tumor genomes Complete list of significantly mutated genes from the colon cancer set. Gene name, representative protein length, and number of mutations are listed.

Format: XLSX Size: 13KB Download file

Open Data

Additional file 3:

Top genes highly mutated in breast cancer tumor genomes Complete list of significantly mutated genes from the breast cancer set. Gene name, representative protein length, and number of mutations are listed.

Format: XLSX Size: 13KB Download file

Open Data

Additional file 4:

Top domains highly mutated in colon cancer tumor genomes Complete list of significantly mutated domains from the colon cancer set. Gene name, Pfam domain accession, number of mutations, cumulative domain length, and genes containing mutations in the domain are listed.

Format: XLSX Size: 12KB Download file

Open Data

Additional file 5:

Top domains highly mutated in breast cancer tumor genomes Complete list of significantly mutated domains from the breast cancer set. Gene name, Pfam domain accession, number of mutations, cumulative domain length, and genes containing mutations in the domain are listed.

Format: XLSX Size: 12KB Download file

Open Data