Resolution:
## Figure 5.
Evaluation of the different pSDC metrics and RNA structure prediction algorithmâ€™s
performances. A.) Receiver Operator Characteristic (ROC) analysis of three representative
metric/algorithm combinations indicating significant differences in the predictive
performance. The three curves are for the RNAsubopt prediction of the Z centroid structure
(for the first 10,000 structures), base-pair probability as computed from the partition
function of RNAfold, and the MFE structures predicted by sFold. B.) Summary of all
Area Under the Curve values for ROC analysis of metric/algorithm combinations. In
general, most algorithms perform equivalently for identifying the mutations that disrupt
RNA structure.
Ritz |