Schematic representation of the four software packages we benchmarked for their ability to predict which mutations in an RNA affect structure most significantly. We chose these packages as they all perform some form of sub-optimal sampling, illustrated with “cartoon” energy landscapes. We also include the precise UNIX commands used to make the predictions.
Ritz et al. BMC Genomics 2012 13(Suppl 4):S6 doi:10.1186/1471-2164-13-S4-S6