Table 1

Scoring the capability of discriminating among disease related and neutral SASs on different set of conformers.

MCC

Accuracy

Specificity

Sensitivity


Global*

0.19

0.54

0.76

0.44

Minimum°

0.23

0.54

0.85

0.34

Maximum°

0.36

0.68

0.69

0.68

Average°

0.25

0.62

0.80

0.5

Random^

0.25

0.60

0.68

0.55


*Global uses all data neglecting the correspondence between proteins and their conformers. °Minimum, Maximum and Average characterize the values of ΔΔG per SAS taking into account the conformers for each protein. ^Random MCC was calculated as an average over 50 independent selections of a randomly taken one ΔΔG value per SAS and per protein. In all the cases the threshold is ± 2kcal/mol. The difference between MCC values for Maximum and Random is significant at P-value=0.02. For definition of the different scoring indexes see text.

Juritz et al. BMC Genomics 2012 13(Suppl 4):S5   doi:10.1186/1471-2164-13-S4-S5

Open Data