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This article is part of the supplement: SNP-SIG 2011: Identification and annotation of SNPs in the context of structure, function and disease

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Predict impact of single amino acid change upon protein structure

Christian Schaefer12* and Burkhard Rost12345

Author Affiliations

1 TUM, Bioinformatics - I12, Informatik, Boltzmannstr. 3, 85748 Garching, Germany

2 TUM Graduate School of Information Science in Health (GSISH), Boltzmannstr. 11, 85748 Garching, Germany

3 Institute of Advanced Study (IAS), TUM, Boltzmannstr. 3, 85748 Garching, Germany

4 New York Consortium on Membrane Protein Structure (NYCOMPS), TUM Bioinformatics, Boltzmannstr. 3, 85748 Garching, Germany

5 Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West, 168th Street, New York, NY 10032, USA

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BMC Genomics 2012, 13(Suppl 4):S4  doi:10.1186/1471-2164-13-S4-S4

Published: 18 June 2012

Additional files

Additional file 1:

Datasets of mutants with observed effects on function and stability. Archive of the two different mutant sets with observed effects along with predictions of their effect on local structure.

Format: ZIP Size: 392KB Download file

Open Data