A sample gene regulatory network. Illustration of the impact of a hypothetical external perturbation on a small portion of the Pancreatic Cancer pathway. The pathway is taken from the KEGG database. The solid rectangles denote the genes affected directly by perturbation, the dashed rectangles indicate genes secondarily affected through the networks. The dotted rectangles denote the genes without any change in expression. → implies activation and ⊣ implies inhibition. In this figure, genes K-Ras, Raf and Cob42Roc are primarily affected and MEK, Ral and RalGDS are secondarily affected through interactions.
Bandyopadhyay et al. BMC Genomics 2012 13(Suppl 2):S2 doi:10.1186/1471-2164-13-S2-S2