Table 2

Significantly regulated transcripts of metabolic pathways in liver tissue within different ontogenetic stages (Ingenuity Pathway Analysis).

Ontogenetic stage

Regulated pathway

Direction of regulation

P value

No. of regulated genes

Genes involved in pathway


94 dpc

Wnt signaling

up

1.20*E-2

9

ACVR1, CSNK1G3, FZD4, FZD6, MAP3K7, MMP7, TCF4, TCF7L2, WNT5A

Mitotic roles of Polo-like kinase

down

5.15*E-8

11

CCNB1, CCNB2, CDC23, CDC25B, CDK1, FZR1, SP90AA1, KIF11, PLK1, PPP2R1B, PTTG1

G1/S checkpoint regulation

down

2.76*E-5

8

CCND2, CCND3, CCNE1, CDK4, E2F1, E2F4, RB1, TFDP1

G2/M DNA damage checkpoint regulation

down

1.53*E-3

5

CCNB1, CCNB2, CDC25B, CDK1, PLK1

1 dpn

-

-

-

-

-

28 dpn

Complement system

up

2.07*E-5

5

C4B, C5, C6, C9, CD55

G1/S checkpoint regulation

down

2.49*E-2

3

CDKN1B, HDAC11, TGFB3

188 dpn

VEGF signaling

up

2.80*E-4

12

ACTA2, AKT3, BCL2, EIF2B1, KDR, MAPK1, MRAS, PIK3R3, PRKCB, RRAS2, VCL, VEGFC

mTOR signaling

up

6.29*E-3

13

AKT3, EIF3B, EIF4B, MAPK1, MRAS, PIK3R3, PPP2CB, PRKAB2, PRKCB, RHOJ, RRAS2, TSC1, VEGFC

Synthesis and degradation of ketone bodies

up

1.18*E-3

4

ACAA1, BDH1, HADHA, HADHB

Bile acid synthesis

up

3.33*E-3

7

ACAA1, ADH5, ADHFE1, ALDH7A1, HADHA, HADHB, LIPA

Fatty acid elongation in mitochondria

up

4.81*E-3

4

ACAA1, AUH, HADHA, HADHB

Glucocorticoid receptor signaling

up

3.99*E-2

17

AKT3, BCL2, CCL2, GTF2A2, GTF2B, GTF2E2, HSP90AB1, HSPA1B, IL1RN, MAPK1, MRAS, NCOR1, PBX1, PIK3R3, RRAS2, TAF4, VCAM1

Val, Leu, Ile degradation

up

8.32*E-3

8

ACAA1, ACAD10, ALDH7A1, AUH, BCKDHB, HADHA, HADHB, HIBADH

Biosynthesis of steroids

down

7.65*E-3

5

CYP24A1, CYP7B1, DHCR7, FDFT1, MVD


The comparison between the dietary gestational protein diets (LP vs. AP) is shown in dependence of the regulatory direction (up or down).

Oster et al. BMC Genomics 2012 13:93   doi:10.1186/1471-2164-13-93

Open Data