Table 2

Effect of a chronic Western diet on the expression of genes related to cholesterol and lipid metabolism in the small intestine a

Symbol

Gene name

FC

q-value


Abca1

ATP-binding cassette, sub-family A, 1

-1.13

0.466


Abcg5

ATP-binding cassette, sub-family G, 5

-1.48

0.006


Abcg8

ATP-binding cassette, sub-family G, 8

-2.35

0.002


Acaa2

acetyl-Coenzyme A acyltransferase 2

1.67

0.010


Apoa2

Apolipoprotein A-II

3.15

0.001


Apoc2

Apolipoprotein C-II

1.36

0.006


Cav1

Caveolin 1

1.6

0.006


CD36

CD36 antigen

2.11

0.020


Ces1d

Carboxylesterase 1D

-6.13

< 0.001


Ces1g

Carboxylesterase 1G

-5.46

< 0.001


Cpt1a

Carnitine palmitoyltransferase 1a, liver

1.55

0.044


Cyp27a1

Cytochrome P450, family 27, subfamily a, polypeptide 1

-2.57

0.004


Cyp51

Cytochrome P450, family 51

2.03

0.001


Dhcr7

7-dehydrocholesterol reductase

1.48

0.011


Hmgcl

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

1.57

0.024


Hmgcr

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

1.02

0.748


Hmgcs2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

8.07

< 0.001


Hsd17b7

Hydroxysteroid (17-beta) dehydrogenase 7

1.32

0.045


Idh1

Isocitrate dehydrogenase 1 (NADP+), soluble

1.31

0.010


LDLr

LDL receptor

4.29

< 0.001


LXRα

Liver × receptor alpha

1.77

0.003


LXRβ

Liver × receptor beta

-1.06

0.646


Me1

Malic enzyme 1, NADP(+)-dependent, cytosolic

3.13

< 0.001


Mttp

Microsomal triglyceride transfer protein

1.18

0.016


Mvd

Mevalonate decarboxylase

1.33

0.012


Mvk

Mevalonate kinase

1.22

0.017


Npc1l1

Niemann-Pick C1-like protein 1

-2.02

< 0.001


Nsdhl

NAD(P) dependent steroid dehydrogenase-like

1.45

0.004


Pcsk9

Proprotein convertase subtilisin/kexin type 9

1.65

0.007


Pmvk

Phosphomevalonate kinase

2.46

< 0.001


Scarb1

Scavenger receptor class B, member 1

1.4

0.447


Scd1

Stearoyl-Coenzyme A desaturase 1

90.7

< 0.001


Scd2

Stearoyl-Coenzyme A desaturase 2

6.50

< 0.001


Slc25a1

Solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1

2.04

< 0.001


Slc27a4

solute carrier family 27 (fatty acid transporter), member 4

-1.12

0.209


Sqle

Squalene epoxidase

2.11

0.011


Srebp-2

Sterol regulatory element binding factor 2

1.59

0.004


Tm7sf2

Transmembrane 7 superfamily member 2

1.52

0.003


a Abbreviations: FC fold change (Western diet vs. control).

Desmarchelier et al. BMC Genomics 2012 13:84   doi:10.1186/1471-2164-13-84

Open Data