Table 5

Highly Expressed SAE-enriched Signaling Ligands and Growth Factors1

Gene symbol

Gene title

Median expression level (RPKM)


MDK

midkine (neurite growth-promoting factor 2)

59.8

CXCL1

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

49.3

CX3CL1

chemokine (C-X3-C motif) ligand 1

32.9

TNFSF10

tumor necrosis factor (ligand) superfamily, member 10

31.8

FSTL1

follistatin-like 1

27.9

CXCL6

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

18.6

FGF14

fibroblast growth factor 14

16.5

DLL1

delta-like 1 (Drosophila)

13.6

JAG2

jagged 2

11.9

IL8

interleukin 8

8.6

CCL15

C-C motif chemokine 15

7.8

PDGFA

platelet-derived growth factor alpha polypeptide

6.1

TNFSF12

tumor necrosis factor (ligand) superfamily, member 12

5.9

CCL23

chemokine (C-C motif) ligand 23

5.3

NMB

neuromedin B

4.9

CCL5

chemokine (C-C motif) ligand 5

4.9

NPFF

neuropeptide FF-amide peptide precursor

4.6

FAS

fas (TNF receptor superfamily, member 6)

3.6

WIF1

WNT inhibitory factor 1

3.6

CCL18

chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

3.5

LTB

lymphotoxin beta (TNF superfamily, member 3)

3.0

LIF

leukemia inhibitory factor (cholinergic differentiation factor)

2.9

ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

2.7

PTCH1

patched homolog 1 (Drosophila)

2.6

WNT5A

wingless-type MMTV integration site family, member 5A

2.1

CCL17

chemokine (C-C motif) ligand 17

1.7

NRTN

neurturin

1.7

AREG

amphiregulin

1.4

CCL4

chemokine (C-C motif) ligand 4

1.3

NTS

neurotensin

1.2


1 The top 30 signaling ligands and growth factors were identified in the highly expressed SAE-enriched list for n = 5 healthy nonsmokers.

Hackett et al. BMC Genomics 2012 13:82   doi:10.1186/1471-2164-13-82

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