Table 4

Highly Expressed SAE-enriched Transmembrane Receptors1

Category

Gene symbol

Gene title

Median expression level (RPKM)


G protein coupled/7 transmembrane

CELSR1

cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

63.0

C5AR1

complement component 5a receptor 1

27.6

GPR110

G protein-coupled receptor 110

21.7

GPRC5C

G protein-coupled receptor, family C, group 5, member C

20.3

OXTR

oxytocin receptor

19.3

LPAR3

lysophosphatidic acid receptor 3

17.6

FZD6

frizzled homolog 6 (Drosophila)

12.5

PTGER4

prostaglandin E receptor 4 (subtype EP4)

9.2

VIPR1

vasoactive intestinal peptide receptor 1

8.8

ADRB1

adrenergic, beta-1-, receptor

7.8

GPR116

G protein-coupled receptor 116

7.5

FZD8

frizzled homolog 8 (Drosophila)

7.1

ADRA2A

adrenergic, alpha-2A-, receptor

6.8

PTGFR

prostaglandin F receptor (FP)

6.6

Cyclase related

NRP2

neuropilin 2

12.0

NPR2

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)

10.7

CRCP

CGRP receptor component

10.4

IgG like

SCARA3

scavenger receptor class A, member 3

21.8

PTPRT

protein tyrosine phosphatase, receptor type, T

13.0

IL1R1

interleukin 1 receptor, type I

6.5

Ion channel

GABRP

gamma-aminobutyric acid (GABA) A receptor, pi

15.7

Serine kinase

TGFBR2

transforming growth factor, beta receptor II (70/80 kDa)

8.8

Tyrosine kinase

DDR1

discoidin domain receptor tyrosine kinase 1

140.3

FGFR3

fibroblast growth factor receptor 3

19.9

IGF1R

insulin-like growth factor 1 receptor

15.2

PTK7

PTK7 protein tyrosine kinase 7

14.5

FGFR2

fibroblast growth factor receptor 2

11.6

MET

met proto-oncogene (hepatocyte growth factor receptor)

8.5

EGFR

epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

7.2

Other

SORL1

sortilin-related receptor, L(DLR class) A repeats-containing

7.7


1 The top 30 transmembrane receptors were identified in the highly expressed SAE-enriched list for n = 5 healthy nonsmokers. They were categorized by structural family and sorted in descending order of expres-sion within each category.

Hackett et al. BMC Genomics 2012 13:82   doi:10.1186/1471-2164-13-82

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