Additional File 4.

Supporting Figure S4: Predictive performance and pairwise correlation of amino acid-associated weights decrease for serum IgG antibodies during the course of the immune response. (A) Predictive performance values (Q2) were computed from serum IgG antibody binding profiles across three stages of immune response: healthy, acute, early chronic. (B) Shown is the pairwise correlation (r) of the corresponding AAWS <a onClick="popup('http://www.biomedcentral.com/1471-2164/13/79/mathml/M34','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/13/79/mathml/M34">View MathML</a>. Number of BALB/c mice serum samples: 15 from healthy mice, after infection with HB: 15 samples taken at 10 dpi and 13 samples taken at 14 dpi (acute phase) and 15 samples taken at 18 dpi (early chronic) totaling 58 BALB/c serum samples. Differences in predictive performance (Q2) between both healthy and early chronic phase mice and healthy and acute phase mice are significant (p < 0.05) as are differences in pairwise correlation (r) between all three stages of immune response (p < 0.001). Antibody binding profiles were measured with the standard peptide library of 255 14-mers. Corresponding AAWS (<a onClick="popup('http://www.biomedcentral.com/1471-2164/13/79/mathml/M30','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/13/79/mathml/M30">View MathML</a>) were computed using Equation 1.

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Greiff et al. BMC Genomics 2012 13:79   doi:10.1186/1471-2164-13-79