Predictive performance and pairwise correlation of AAWS decrease for serum IgM antibodies in the course of the HB-infection. (A) Predictive performance values (Q2) were computed from serum IgM antibody binding profiles across three stages of immune response: healthy, acute, early chronic. (B) Shown is the pairwise correlation (r) of the corresponding AAWS . Numbers of BALB/c mouse serum samples: 15 samples from healthy mice; after infection with HB: 15 samples at 10 dpi and 13 samples at 14 dpi (acute phase), and 15 samples at 18 dpi (early chronic) totaling 58 BALB/c mouse serum samples. Differences in predictive performance (Q2) between healthy and both acute phase and early chronic phase mice are significant (p < 0.01), as are differences in pairwise correlation (r) between all three stages of immune response (p < 0.001). Antibody binding profiles were measured with the standard peptide library of 255 14-mers. Corresponding AAWS () were computed using Equation 1.
Greiff et al. BMC Genomics 2012 13:79 doi:10.1186/1471-2164-13-79